Lexicon

Anemia, hemolytic

= Abnormal increased erythrocyte dissolution:
     - Shortened erythrocyte lifetime
     - Compensatory enhanced erythropoiesis
     - Increase in indirect bilirubin
     - Haptaglobin in the serum
     - Possibly also hemoglobinuria

Aphasia, amnestic
= Word-finding disorder with preserved terminology and language understanding and in case of intact spontaneous erythrocyte eruption

Arteriole
= Very small blood vessels passing in capillary, which lead the blood from the heart to an organ or tissue.


Endothelium
= Cell layer on the inner surface of the blood and lymph vessels


Erythrocyte
= Red blood cell, which carries out the oxygen transport in the organism with its hemoglobin and performs active ATP-dependent metabolic performances


focal
= concerning a disease

   
Fragmentocyte
= Strong deformed erythrocyte, especially in intravascular hemolysis

Vascular lesion
= Injury or disturbance of the function of a vessel


Hemoglobin (Hb)
= The red blood dye and its variants
= In the narrow sense, the normal HbA1 contained in the erythrocytes

 
Hemoglobinaemia
= Occur free hemoglobin in the blood with severe hemolysis as a consequence of inadequate binding by the haptoglobin, possibly with hemoglobinurie

 

Hemiplegia
= Complete or incomplete paralysis of one half of the body

 
Hyaline
= Glassy-transparent protein mass converted from tissues

Ischemia
= Pathological exsanguination or poor blood circulation of a tissue due to insufficient or missing arterial blood supply
= Leads to oxygen deficiency, with fading, cooling and volume reduction of the affected tissues


occlusion
= Closure

 
Microangiopathic
= Changes of small and small arteries

 
Microangiopathy, thrombotic (TMA)
= Describes the vascular problem with TTP:

The vascular sections are completely occluded by thromboses formed from platelets and von Willebrand factor. They show a swelling and proliferation of the endothelium - but no inflammatory reaction. There are deposits of hygienic material that is not fibrin.

Petechiae
= Smallest, punctual skin or mucosal bleeding (capillary bleeding)

Petechia small
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Proteinase
= Protein-cleaving enzymes (= mostly proteins):
Proteases cleave the proteins as enzymes


Thrombocyte
= Blood platelets

Platelet aggregation
= In two-phase clumping of thrombocytes in the course of the physiological bleeding, mediated by a glycoprotein complex of the membrane (envelope of the thrombocyte), but also in the pathological development of a thrombus

Reversible Phase:
On contact with free collagen fibrils (e.g., injured vessel wall) and ADP or with immune complexes, thrombocyte aggregation is increased, clumps are formed which, however, can still disintegrate.

Irreversible phase:
The platelet aggregates no longer disintegrate.

Thrombus
= A thrombus consists of several platelet aggregates and fibrin. It is always pathological.

 
Willebrand factor
= Large protein, which influences the interaction between platelets and the blood vessel walls. It is formed by the vessel endothelium and megakaryocytes.
= Protective protein for Factor VIII
= Transport protein for factor VIII in the blood
= Adhesive protein, which adheres to the adhesion of platelets to the site of injury